一群摩托车手，其中有几个人是The Hills Have Eyes Part第一部中的幸存者，他们准备开大巴士去沙漠附近一个声名狼藉的地方参加一场摩托车比赛。但是他们出了点小问题，怕赶不上决定抄捷径穿过沙漠。半路上巴士坏了，当他们修理巴士的时候，其中几个摩托车手在沙漠中转悠迷失了方向，恐怖的事情开始了……他们来到了一所空房子，空房子里有这么一家人，全都十分怪异加变态，且长相十分可怕。这些误入空房子的人们最终只有一个能逃脱，那么谁会是幸存者呢……
Plot Summary:A group of bikers, which includes some of the survivors from the original film, embark on a journey by bus to a biker race near the desert of the infamous incidents. However, because of a mistake they are late and decide to take a shortcut through the desert. Halfway through the desert the bus breaks down. While trying to repair the bus, some of the group wander off, and wind up in the traps of the survivors of the mutant family of the first. Then the mutants go after the rest...
